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Posts Tagged ‘prostate cancer’

The prostate is a gland found only in men, which lies just below the bladder. The tube through which urine flows from the bladder when you pass water goes first through the prostate gland then out through the penis. The prostate gland can become enlarged in many men as they get older which then causes difficulty with urination.

The job of the prostate gland is to produce fluid which forms part of semen and helps to nourish sperm. The prostate gland sits in front of the back passage or rectum which is why if a doctor wants to examine the prostate gland they feel it by putting a finger into your back passage. This is also called a digital rectal examination or DRE for short. From feeling the prostate gland the doctor can tell how enlarged the gland is and whether it feels normal or cancerous, this can then provide a picture of prostate cancer if it exists.

Cells in the prostate gland are constantly turning over to replace old with new but sometimes this process can get out of control. Cancer is the name for cells which have lost control of their renewal process and start to grow unchecked. They grow into a group of cells called a tumour. As the cells grow they can start to invade surrounding tissues. This invading process is called acting in a malignant fashion. Cells can break off the tumour and spread to other sites in the body, usually via the blood stream. The cells can then grow where they have settled, often in distant parts of the body such as the bones or brain. These deposits are often called secondaries or metastases. These deposits are not new cancers but are groups of cancer cells spread from the original or primary cancer in the prostate gland.

Most often in prostate cancer this process of tumour growth followed by invasion then metastasis is relatively slow and can occur over many months or years. This is why some men may have prostate cancer but never have a problem because of it i.e. their prostate cancer grows so slowly that other diseases or illnesses (e.g. heart attack or stroke) cause problems or even death before the prostate cancer has developed far enough to cause symptoms or spread from the prostate. With modern treatments many men with early prostate cancer can be cured and in many more the prostate cancer can be controlled and the invasion process slowed even more. Prostate cancer survival rates vary widely around the world, although detection in 3rd World countries is often poorly catalogued.

The cause of prostate cancer is not known. What is known is the characteristics of those men who tend to develop prostate problems. These are known as risk factors i.e. men with these characteristics are at greater risk of developing the cancer. However it is important to realise that ALL men are at risk of prostate cancer and even young men who have no history of cancer in their family can develop prostate cancer.

Age

Age is the main risk factor for developing prostate cancer. As men get older they have a higher chance of developing all types of cancer including cancer of the prostate. Prostate cancer is quite uncommon below the age of 50 years however four out of every ten men who are 70 years or older will have the illness. Many of these men will live normally without knowing they have prostate cancer and without it giving them any symptoms or shortening their life span.

Hormones

We know that the male hormones tend to stimulate the development of prostate cancers and prostate cancer is very rare in men who have been castrated before the age of 40 years. This is likely to be because the normal prostate gland is affected by male hormones when carrying out its normal functions in the body. Prostate cancer cells originate and have some features similar to these normal prostate cells including being influenced by male hormones.

Race

Prostate cancer is seen more commonly in certain ethnic groups e.g. African-Americans.

Diet

Diet may have an influence on the development of prostate cancer. Prostate cancer is more common in men who have a western diet high in saturated fats. Saturated fats are found in red meats such as beef, lamb etc and in some dairy produce e.g. butter and things made with butter e.g. cakes, biscuits etc., and also in highly processed foods e.g. ready meals. It seems that men who have a diet high in saturated fat are at increased risk of developing prostate cancer. It is also widely believed that a diet high in fruit and vegetables helps to prevent many cancers. This may be through the action of cancer protective chemicals found in many fruit and vegetables known as anti-oxidants. This is one of the reasons it is recommended that we include five portions of fruit and vegetables in our diet every single day.

Genetic

Prostate problems also tend to run in some families which could suggest part of the cause of some prostate cancers is genetic or hereditary. If your father or brother has prostate cancer your chance of developing it is about double that of the general population. However only a small number of all prostate cancers are caused by a known faulty gene and most occur at random.

SUMMARY OF PROSTATE CANCER CAUSES

Age (prostate cancer is more common as men get older)

Male hormones (prostate cancers uncommon in castrated men)

Ethnic group (prostate cancer more common in African-Americans)

Genetic (prostate cancer can run in families)

Diet

Author: Adrian Jones
Article Source: EzineArticles.com
Provided by: Guest blogger

Breast cancer is a largely unknown disease until today, despite the fact that it affects almost ten percent of the women above the age of forty years all over the world. The causes of this killer cancer are not known even after decades of research into it. Similarly it is unknown why some women have higher chances of getting breast cancers than others.

Though the causative factors are not known, some risk factors have been identified. There is no medical proof why these factors make the disease more probable, but this is a study of observation. In a vast cross-section of women with the observed risk factors, it has been found that the chances of getting breast cancers are very high.

The various risk factors for breast cancer are as follows:-

(1) Family History of Breast Cancer

If a near relative like a mother or a sister has had breast cancer, then there is a very high chance that the cancer will occur sometime in life. This propensity is observed even if far relatives such as cousins and aunts have had breast cancer, though the chances are lesser as the relatives are more removed. Even if a male relative has had breast cancer or prostate cancer, then there is a chance of getting breast cancer. This clearly indicates that breast cancer runs through family lines through inheritance. Certainly the chances are very high if more than one family member has had breast cancer.

(2) Personal History of Breast Cancer

If a woman has had breast cancer in the past, then there is a great chance that the breast cancer may recur. This is true even if the cancer had been removed in its benign stage itself. Sometimes the cancer cells spread into the nearby lymph. This makes a possibility that the cancer will occur in the opposite breast. In fact, women who have had cancer in one breast have 50 to 75% more chances of developing the cancer in the other breast.

(3) Diseases of the Breast

Several breast diseases can increase the chances of having breast cancer. Changes in the cells of the breasts can lead to atypical hyperplasia. This condition can cause a three to fourfold increase in the possibility of getting breast cancer in the later years. This risk also exists if the atypical hyperplasia has occurred in other women of the family. Another such condition is the benign breast tumor condition known as fibro adenoma. However, women with fibrocystic breasts generally do not have any added vulnerability to breast cancer. Yet, such conditions could make the breasts lumpy and hide the real tumors (if any) during mammography.

(4) Lifestyle

In todays world, lifestyle is the single largest contributing factor for the proliferation of breast cancer among women. Several elements of the lifestyle have been found to be directly accordant with the prevalence of breast cancer. Smoking and alcoholism in women are among the chief factors. Even diet has been pointed out as an important risk factor. Women who consume a diet with more high-cholesterol fats in them have higher chances of breast cancer. At the same time leading a sedentary lifestyle without indulging much in physical activity are also potentially dangerous.

(5) Radiation

It has been found that women who undergo radiation therapies in their chest region at a young age have an increased risk of developing breast cancer in their later lives. Radiation therapy is generally prescribed for women with conditions like Hodgkins disease or non-Hodgkins lymphoma. So women who have undergone such treatments may get breast cancer in their later years.

(6) Hormonal Imbalances There are several factors that can change the hormone balance of the body. Some of them are:- a) Beginning the menstrual cycle early, i.e. before the age of twelve years, b) Having the first pregnancy after the age of thirty years, c) Having no pregnancy at all, d) Having a late menopause. All these conditions can increase the level of estrogen in the body. This increases the risk of getting breast cancer to a mild extent. Apart from that women who take regular birth control pills, breast enhancement supplements, antidepressants and antihistamines and hormone modifying supplements stand at a higher risk to get breast cancers.

The above are the major risk factors for breast cancers. But since the study on breast cancers is not yet complete, the above is by no means a complete list. There are several other indications of breast cancers, like breast implant operations; but these have not yet been confirmed. The implants used in the earlier days were made of silicone gels. These were riskier in terms of breast cancer. However, nowadays the silicone gel implants have been replaced by saline implants. This has reduced the risk to a great extent.

It must be also noted that women have much higher chances of getting breast cancer than men. In fact, most people think that breast cancer is a disease that affects only women. This is not true. Men also get breast cancers, but to a much lesser degree than women. Also, age is a very important factor. The chances of getting breast cancer are much higher when the woman has crossed the age of 50 years.

Author: Anna Hardy
Article Source: EzineArticles.com
Provided by: Canada duty rate

Prostate cancer is the most commonly diagnosed non-skin cancer, has overtaken lung cancer as the leading cancer affecting all men and followed by colorectal cancer.

Statistically, 80 percent of prostate cancers occur in men over the age of 65. Although this cancer can also occur in younger individuals, it is very rare under the age of 50. As males age the prostate can develop problems.

Annually, one out of six American men will develop it in the course of his lifetime. Little did we know the fact a man is 33% more likely to develop prostate cancer than a woman is to get breast cancer.

In 2004, it is estimated that 234,000 new cases of prostate cancer diagnose in the United States. That makes it the most common cancer among American men, next to the skin cancer. More than 27,000 deaths due to prostate cancer are expected to occur annually.

One new case every 2 1/2 minutes. One new case every 150 seconds.

While in UK, nearly 35,000 men are diagnosed and about 10,000 men die from prostate cancer annually. This means over one man die every hour in UK.

Today, about two million men are fighting prostate cancer, and over the next decade, as baby boomer men reach the target ripen age for prostate cancer, about three million more will be compelled to join the battle. It is estimated that by 2012, the number of new cases in the U.S. is expected to increase to more than 300,000 new cases per year by 2012.

One new case every 100 seconds. One man dead every 13 minutes.

What is prostate?

Prostate is a male sex gland, the size of a walnut, located behind pubic bone in front of the rectum that encompasses lower part of a bladder. The tube that carries urine (the urethra) runs through the prostate. At birth the gland size is small like a pea and it continue to grow until age of 20 when a man reaches adulthood. Male hormones (called androgens) is responsible for this growth. The gland size will not change until 45, when it starts to grow again.

Its primary function is to produce thick fluids that nourish the sperm, as well as helping propel sperm through the urethra and out of the penis to reach and fertilize an egg. Even though prostate is not a primary component of urinary tract, but it is very important for urinary health.

In older men, the part of the prostate around the urethra may keep on growing. This causes BPH (benign prostatic hyperplasia) which cause problems passing urine. BPH is a problem that must be treated, but it is not cancer.

What is prostate cancer?

The body is made up of different types of cells. Normally, cells grow, divide and then die. Sometimes, cells mutate and begin to grow and divide more quickly than normally. Instead of dying, these abnormal cells clump together to form tumors. If these tumors are cancerous or so-called malignant tumors, they can invade and kill healthy tissues in the body. From these tumors, cancer cells can metastasize (spread) and form new tumors in other parts of the body. In contrary, non-cancerous tumors or so-called benign tumors do not spread to other parts of the body.

Prostate cancer is abnormal cells grow out of control forming small nodules or bumps (overgrowth tissue) on the surface of in the prostate gland. In some cases, the overgrowth tissue is benign and this prostate condition is called Benign Prostatic Hypertrophy (BPH). Other times, abnormal cancerous cells characterize the overgrowth of tissue, and this is referred to as a malignancy or prostate cancer.

As its close proximity to the bladder, prostate disorder might interfere with urination and causing bladder or kidney problems. It is also located immediately next to the nerves responsible for erections hence it might interfere with sexual function as well.

Although more than 70% of all prostate cancer cases are diagnosed in men over the age of 65, doctors recommend that every man above the age of 50 should have a PSA test and a rectal exam. According to statistic African-American have almost twice as much prostate cancer incidence rates as Caucasian American, hence they should start getting tested at age 40. The same is true if you have a
family history of prostate cancer.

One-third of men over the age of 50 have some cancer cells within their prostate and nearly all men over the age of 80 have a small area of prostate cancer. In most men, these cancers grow extremely slowly, particularly in elderly men, and it will never cause any problems. Even without treatment, many of them will not die of the prostate cancer, but who, but rather live and die of some other unrelated cause before the disease takes its toll.

However, similar to most types of cancer, if left completely unchecked prostate cancer can be aggressive, grow more quickly and may spread (metastasized) to other parts of the body, particularly lymph nodes or the bones. This makes treatment much more difficult.

What are the symptoms?

Prostate cancer often does not cause any symptoms for years. When symptoms do occur, usually the cancerous cells have spread beyond the prostate, this is why regular check up for men age of 40 and above is necessary and recommended. The symptoms include:

• Urinary problems:
• Dull pain in the lower pelvic area, hips, or upper thighs
• Not being able to urinate
• Sensation that your bladder doesn’t empties
• Having a hard time starting or stopping the urine flow
• Problems with urgency of urination and difficulty in starting
• Frequent urination, especially at night
• Weak flow of urine
• Urine flow that starts and stops
• Pain or burning during urination
• Difficulty having an erection
• Pain at ejaculation
• Genital pain
• Blood in the urine or semen

Note: Other health issues such as urinary infection or inflammation; bladder problems or kidney stone can cause exactly the same symptoms. Hence, should those symptoms occurred and accompanied with blood in your urine, painfully ejaculation and general pain in your lower back, hips and leg bones, significant lost of weight – you must inevitable visit your urologist for a thorough check up.

Who are at risk?

Risk factors consistently associated with prostate cancer include:

• Age: After the age of 50, the chance of developing prostate cancer is higher. More than 80 percent of all prostate cancers occur in men 65 years and older.
• Race: African American men have a 60% higher risk of prostate cancer than white men, including Hispanic men
• Ethnicity: More common in North America and northwestern Europe and occurs less frequently in Asia, Africa, Central
  America and South America.
• Family history: Appears to have a genetic link. Having family history of prostate cancer, a father or brother with the disease doubles a man’s risk of developing it. Man whose brother had a prostate cancer have 4.5 times higher risk of prostate cancer and 2.5 time higher if his father had a prostate cancer.
• Vasectomy: Men who have undergone vasectomy (a surgical procedure that renders them sterile) may have an increased risk.
• Men who have diabetes have less risk of getting the disease, although no one really knows why.

How to prevent?

Maintaining a healthy lifestyle is the best way to reduce the risks from all forms of cancer:

• Diet: The results of most studies show s diet high in animal fats and low in fresh fruit and vegetables have an increased chance of developing prostate cancer.
• Studies show a diet high in lycopenes (found in higher levels in colorful fruits and vegetables), selenium, goji berry, broccoli and turmeric may lower the risk of developing prostate cancer.
• Exercise: Maintaining a healthy weight along with regular physical activity may reduce the risk of prostate cancer.
• Get plenty of rest- regularly scheduled bed time is important for overall health.

How is prostate cancer detected?

There are three common screening methods for prostate cancer:

• Digital rectal examination (DRE)
  A digital rectal examination as part of an annual physical exam in men age of 50 or older (and in younger men who are at increased risk). During this test, a doctor inserts a gloved and lubricated finger into the rectum to feel for abnormalities. While the rectal exam may be a bit unpleasant, it is done quickly.
• Blood test for prostate specific antigen (PSA)
  The PSA is a blood test which measures a protein in prostate gland cells. The American Cancer Society recommends the test to be executed once a year for men 50 and older, and for younger men with higher prostate cancer risk.

Results under 4 are usually considered normal. Results above 10 are considered high. Values between 4 and 10 are considered borderline. The greater the PSA level, the greater the chance that prostate cancer exists.

The test need to be validated further with a biopsy as the PSA test cannot be used as a foolproof test for prostate cancer:

• 2 out of 3 men with a high PSA values show no cancerous cells in their prostate biopsy.
• 1 in 5 men with prostate cancer will have a normal PSA result.
• Transrectal ultrasound (TRUS)
  TRUS will be done if the digital rectal exam or PSA levels are abnormal. A probe is inserted into the rectum and pictures are recorded using sound waves, which create an image of the prostate gland. The test is usually done in outpatient setting and usually takes less than 30 minutes. Based on results from these screenings, additional tests may be recommended.

A positive biopsy is needed to confirm the diagnosis. If a biopsy reveals cancer, additional testing is done to see if it has spread to other organs:

• Blood tests- may be taken to see if the cancer has spread
• Bone scan- to determine if the cancer has spread to the bones
• CT scan- a series of x-ray images taken of the pelvis or abdomen, often used to determine general signs of disease
• Chest x-ray- to determine if cancer has spread to the lungs
• MRI- magnetic resonance imaging to detect cancer in lymph nodes and other internal organs

What is the usual treatment for prostate cancer?

There are several treatments to treat prostate cancer: These include surgery, radiotherapy and various forms of drug treatment. Hormone therapy is commonly used. It blocks the action of testosterone, a sex hormone that prostate cancers need in order to grow.

Three treatment options are generally accepted for men with localized
prostate:

• Radical prostatectomy: A surgical procedure to remove the entire prostate gland and nearby tissues. In some cases the lymph nodes in the pelvic area are also removed. This procedure is performed using nerve-sparing surgery which might prevent damage to the nerves needed for an erection. However, nerve-sparing surgery is not always possible.
• Radiation therapy: Using energy to the prostate using an external beam of radiation. Patients with high-risk prostate cancer are candidates for adding hormonal therapy to standard radiation therapy.
• Active Surveillance may be an option recommended for patients with early-stage prostate cancer, particularly those who have low-grade tumors with only a small amount of cancer seen in the biopsy.

Are there any side effects?

As with all disease, treatment may result in side effects. The most concern side effects of are impotence, or erectile dysfunction, and incontinence.

Researchers still do not fully understand what causes prostate cancer, or how it develops – and they urgently need to improve on current treatments.

Author: Irwan Lee
Article Source: EzineArticles.com
Provided by: Guest blogger